Valsartan for high blood pressure

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Valsartan for hypertension: mechanism of action, application and clinical evidence High blood pressure (arterial hypertension) is one of the most common cardiovascular disease worldwide and failure is a major risk factor for heart attack, stroke, and kidney. An effective reduction in blood pressure diseases is therefore of crucial importance for the prevention of this episode. One of the modern active ingredients for the treatment of hypertension, Valsartan, a selective Angiotensin II Receptor Antagonist (AT1‑Receptor Blocker). Mechanism of action Valsartan works by selective Blockade of AT1‑receptors, which are important for the effect of Angiotensin II is responsible. Angiotensin II is a potent vasoconstrictor organic peptides and plays a Central role in the Renin‑Angiotensin‑aldosterone‑System (RAAS), which regulates blood pressure and fluid and electrolyte balance. Due to the inhibition of the Angiotensin‑II‑effect of Valsartan leads to: Vasodilatation (enlargement of blood vessels), Reduction in Aldosterone secretion, Decrease of peripheral vascular resistance, Lowering of blood pressure. In contrast to ACE inhibitors, Valsartan does not cause a persistent cough, since it affects the Kinin metabolism. Clinical Application Valsartan is used for the treatment of essential hypertension in adults and children 6 years of age. In addition, it is contraindicated in: Congestive heart failure (to improve the survival rate and reduction of hospitalizations), after a myocardial infarction with reduced left ventricular ejection fraction. Diefangsdosis in hypertension is typically 80 mg once daily; the dose may be increased if necessary to 160-320 mg/day. It is taken regardless of meals. Efficacy and studies The efficacy of Valsartan have been demonstrated in several randomized controlled trials. An important study, VALIANT (Valsartan in Acute Myocardial Infarction Trial), showed that Valsartan may reduce cardiovascular mortality after myocardial infarction significantly. In the study, the VALUE (Valsartan Antihypertensive Long‑term Use Evaluation), it was shown that Valsartan provides effective blood pressure control and the risk of cardiovascular events is reduced. Side effects and contraindications Among the possible side effects of Valsartan: Headache, Dizziness, Hypotension, Hyperkalieämie (increased Potassium levels in the blood), Renal function disorders (rare). Contraindicated Valsartan is: severe liver disease, bilateral renal artery stenosis, Pregnancy and breast-time (as it can cause fetal damage), known Hypersensitivity to the active substance. Conclusion Valsartan is an effective and well-tolerated antihypertensive agent with a broad spectrum of applications. Due to its specific mode of action in the RAAS, it is not only suitable for the treatment of high blood pressure, but also for secondary prevention of cardiovascular diseases. Clinical studies support its role as an important drug in the modern cardiovascular therapy. Would you like me to make a certain section in more detail, or to add more information about an aspect?

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Valsartan for high blood pressure

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Valsartan for high blood pressure. The risk of cardiovascular diseases, inflammation.